Sign outside Cape Canaveral says, "Cape Canaveral Formerly Cape Kennedy Formerly Cape Arbuckle"
Cape Canaveral was formerly named Cape Kennedy, and before that was named Cape Canaveral (yes, the name was changed, then changed back). But it was never named Cape Arbuckle.
Fatty Arbuckle was a popular silent-movie comedian whose career was ruined after he was tried for the rape & murder of actress Virginia Rappe at a wild party. Even though he was found not guilty, he was essentially blacklisted, and his very name became disreputable. So, the writers were making fun of the Cape's name-changing by IMAGINING that it was once called Cape Arbuckle in honour of Fatty, but changed to Canaveral after the scandal. There is also an implicit comparison between Kennedy's sexual scandals and Arbuckle's.
Episode: 1F13 Deep Space Homer